TOP1 - Wikipedia
It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the …
TOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody
2026年1月15日 · TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Hematologic Cancer and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal …
R-loop disruption triggers irreversible topoisomerase 1-DNA ...
2 天之前 · Class switch recombination (CSR) and somatic hypermutation are essential mechanisms of effective antibody production, dependent on the enzyme activation-induced cytidine deaminase …
TOP1 - DNA topoisomerase 1 - Homo sapiens (Human) - UniProt
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single …
Abstract 2967: Evolution of TOP1 variants under selective ...
2 天之前 · TOP1 alterations can appear after exposure to topoisomerase-payload ADCs or irinotecan-containing regimens, suggesting a potential resistance mechanism in a subset of patients. The …
Topoisomerase I in Human Disease Pathogenesis and Treatments
2016年5月12日 · Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA …
TOP1 TRENDING ACROSS REGIONS on WeTV! # ...
2 天之前 · 🏆 TOP1 TRENDING ACROSS REGIONS on WeTV! 🔥 🌙 #LoveBeyondTheGrave Ranked TOP1 globally on WeTV in multiple regions! 🥇🥰 Starring #Dilraba #ChenFeiyu 🔗👉🏻 u.wetv.vip/LoveBeyondtheG…
The Potential of Topoisomerase Inhibitor-Based Antibody–Drug ...
Here, we review the importance of TOP1 inhibitor-based ADCs (TOP1-ADCs) in cancer therapy, the current state of knowledge regarding the design of TOP1-ADCs, and TOP1-ADCs under development.
Entry - *126420 - TOPOISOMERASE, DNA, I; TOP1 - OMIM
2023年11月17日 · The reported studies extended the role of Top1 to include the processing of rNMPs in genomic DNA into irreversible single-strand breaks, an activity that can have distinct mutagenic …
TOP1 - an overview | ScienceDirect Topics
TOP1 refers to Topoisomerase 1, a highly conserved enzyme essential for relaxing supercoiled DNA and facilitating transcription and replication processes.